ESIS Rational Drug Design & Development Group

08.06.2021

Prof. Esin AKI-YALCIN, Ph.D.

URL : http://80.251.40.59/ankara.edu.tr/esinaki/

Email : esinaki@ankara.edu.tr

Tel : +90 (312) 223 69 40

Educational and Administrative Background

1974-1978: B.Sc. at Gazi University, Faculty of Pharmacy
1983: Ph.D. at Ankara University Faculty of Pharmacy Department of Pharmaceutical Chemistry
1986-1987: Assistant Professor at Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
1987: Associate Professor Degree
1988-1993: Associate Professor at Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
1993-Present: Full Professor at Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
1999-2002: Ankara University, Faculty of Pharmacy, Head of the Department of Pharmaceutical Chemistry
2003-2006: Ankara University, Faculty of Pharmacy, Chair of Pharmaceutical Sciences Division
2007-Present: President of the Computer Aided Drug Design and Development Society in Turkey
2008-2012: Assistant to the President of Ankara University

Language Background

Turkish (Native Language)
English (Fluent)
Spanish (Beginner Level)

Doctoral Theses Supervised

Ozlem TEMIZ, 1998, “Synthesis, Structure Elucidation, Microbiological Activity and Quantitative Structure-Activity Relationship Analysis of 5-(2-Furylcarboxamido)-, 5-(2-Thienylcarboxamido)-, 5-Benzamido- and 5-phenylacetamido- 2-phenylbenzoxazole Derivatives”
Sabiha ALPER-HAYTA, 2009, "Synthesis, Structure Elucidation, Antimicrobial Activity and Molecular Modelling Studies of Novel Benzoxazole compounds"

Master Theses Supervised

Hulya TURGUT, 1989, “Synthesis, Structure Elucidation and Microbiological Activity of 5-Substituted-2-(3-pyridyl)benzoxazole Derivatives”
Ozlem TEMIZ, 1991, “Synthesis, Structure Elucidation and Microbiological Activity of 5-Methyl-2-(p-substitutedbenzyl)benzoxazole Derivatives “
Cengiz ERTAS, 1998, “Studies on Synthesis, Structure Elucidation and Microbiological Activity of Possible Metabolites of Benzoxazoles, 4-Substituted-N-(2-hydroxy-5-nitrophenyl)benzamide ve Benzene-acetamide Derivatives”
Kamuran Kadri BINGOL, 1994, “Studies on Synthesis and Microbiological Activity of Possible Metabolites of Benzoxazoles”
Sabiha ALPER, 2002, “Studies on Synthesis, Structure Elucidation and Microbiological Activity of Ethyl-3,4-dihydro-6- and/or 7-substituted-3-oxo-2H-1,4-benzoxazine-2-acetate ve ethyl 3,4- dihydro -N(4)-methyl-6- and/or 7-substituted-3-oxo-2H-1,4-benzoxazine-2-acetate”
Murat YILMAZ, 2004, “Oral Antidiabetic Drugs”

Editorial Board Memberships

ARKIVOC Journal
Current Computer Aided Drug Design Journal
Journal of Faculty of Pharmacy of Ankara University

Symposium and Meeting Organizations

Chair of the “15th European Symposium on Quantitative Structure-Activity Relationships”, Istanbul, September 05-10, 2004.
Chair of the Organizing Committee of the "Workshop on Computer Aided Drug Design & Development", Istanbul-TURKEY, February 02-05, 2007.
Chair of the Organizing Committee of the “6th AFMC International Medicinal Chemistry Symposium", Istanbul-TURKEY, July 01-04, 2007.

Memberships

International QSAR and Modelling Society
American Chemical Society
Ankara University Alumni Association
Turkish Association of Pharmaceutical and Medicinal Chemistry
Computer Aided Drug Design and Development Society (CADD&D Society) in Turkey
The Society of Pharmaceutical Sciences of Ankara (FABAD)
Development Association of Ankara University, Faculty of Pharmacy

Artículos Científicos

Patentes

Artículos de Revisión

8

ALPER, S., TEMİZ-ARPACI, Ö., AKI-ŞENER, E., YALÇIN, İ.,”Some New bi-and ter-benzimidazole Derivatives as Topoisomerase I Inhibitors”, Il Farmaco, 58, 497-507, (2003). [texto íntegro]
7

YALÇIN, İ., ŞENER, E., "Türkiye İlaç Endüstrisinde Özgün İlaç Etken Maddesi Tasarım ve Geliştirilmesi Çalışmalarının Önem ve Gereksinimi", İlaç ve Kimya Endüstrisi İşverenler Sendikası Yayını, 99-100-101, 4-5, (1996). [in Turkish]
6

TEMİZ, Ö., ŞENER, E., "Newly Developed Benzodiazepine Derivatives and Their Biological Activites", J. Fac. Pharm. Ankara, 23(1-2), 37-52, (1994). [in Turkish] [texto íntegro]
5

TEMİZ, Ö., ŞENER, E., "The Microbiological Activity of Benzoxazole, Benzimidazole and Oxazolo(4,5-b)pyridine Derivatives", J. Fac. Pharm. Ankara, 21(1-2), 36-52, (1992). [in Turkish] [texto íntegro]
4

YALÇIN, İ., ŞENER, E., "The Studies on the Searching and Developing of Antiinflammatory, Analgesic and Antipiretic Active Quinazolinon Derivatives", Bulletin of Ankara Chamber of Pharmacists, 8(4), 269-276, (1986). [in Turkish] [texto íntegro]
3

ŞENER, E., YALÇIN, İ., "The Role of Histamine in Inflammation, Activity of the Antiinflammatory Compounds against Histamine", Bulletin of Ankara Chamber of Pharmacists, 8(2),99-110, (1986). [in Turkish] [texto íntegro]
2

YALÇIN, İ., ŞENER, E., "The Structure-Activity Relationships of Selective Antiinflammatory Active Nonacidic Polyaryl Heterocyclic Compounds", FABAD J. Pharm. Sci., 10(3), 183-194, (1985). [in Turkish] [texto íntegro]
1

BÜYÜKBINGÖL, E., ŞENER, E., "The Meaning of Structure-Activity Relationships in the Medicinal Chemistry Concept", Pharmacia-JTPA, 24: 52(2), 126-133, (1984). [in Turkish] [texto íntegro]

Presentaciones Orales

Presentaciones Diapositivas

Artículos del Congreso

5

AKI, E., YALCIN, I., YILDIZ, I., TEMIZ-ARPACI, O., BOLELLI, K., ERTAN-BOLELLI, T., DNA-Topoisomerase Inhibitory Activity of Some Heterocyclic Compounds and Their Structure-Activity Relationships", Med. Chem. Res., 19(Suppl.), S6, (2010). DOI 10.1007/s00044-010-9296-3 [texto íntegro]
4

YALCIN, I., AKI, E., YILDIZ, O., TEMIZ-ARPACI, O., “Antimicrobial Activity and Structure-Activity Relationships of Some Synthesized Benzazoles and Their Possible Metabolites”, Med. Chem. Res. 19 (Suppl. 1), S41, (2010). DOI: 10.1007/s00044-010-9296-3 [texto íntegro]
3

TEMİZ-ARPACI, Ö., TEKINER-GULBAS, B., YILDIZ, İ., AKI-ŞENER, E., YALCIN, İ., "3D-QSAR Analysis on Benzazole Derivatives as Eukaryotic Topoisomerase II Inhibitors by using Comparative Molecular Field Analysis Method", QSAR and Molecular Modelling in Rational Design of Bioactive Molecules, Istanbul-Turkey, September 5-10, 2004, AKI-ŞENER, E., YALÇIN, İ. (Eds.), Başkent Publishing, Ankara, pp.396-398, (2006). [texto íntegro]
2

VARGA, A., AKI-SENER, E., YALCIN, I., B., CHEREPNEV, G., MOLNAR, J., “Induction of Apoptosis and Necrosis by Resistance Modifiers Benzazoles and Benzoxazines on Tumour Cell Line Mouse Lymphoma L5718 MDR+Cells”, Anticancer Research, 24(533), 3663, (2004). [texto íntegro]
1

AKBAY-YARPUZLU, A., YILDIZ, İ., TEMIZ-ARPACI, Ö., KARAGENÇ, N., AKI-ŞENER, E., YALÇIN, İ., “Adenosine Deaminase Inhibitor Activity of Some Benzoxazole, Benzimidazole, and Oxazolo(4,5-b)pyridine Derivatives”, XIII. Biotecnological Congress Proceedings Book, Çanakkale, 21-26, (2003).