ESIS Research Areas

Synthesis and structure elucidation of fused heterocylic compounds;

• Benzoxazoles
• Benzothiazoles
• Benzimidazoles
• Benzoxazines
• Possible metabolites of benzoxazoles:
  • Benzamides
  • Phenylacetamides
  • Furamides

Design of antibacterial, antifungal, antiviral, antitumor and anti-HIV active compounds;

• Gram-positive bacteria
• Gram-negative bacteria
• Fungi
• DNA-topoisomerase I inhibitory activity
• DNA-topoisomerase II inhibitory activity
• Activity against measles virus
• Genotoxic and Mutagenic activity
• Measles virus inhibitory activity
• Anti-HIV activity against HIV-1 reverse transcriptase
• Multiple drug resistantant activity:
  • Apoptosis on tumor cells
  • Revearsal of multidrug resistance
  • Activity in multidrug-resistant variance of cancer cell lines

Computer aided drug design;

• 2D-Quantitative Structure-Activity Relationship studies:
  • Hansch Analysis
  • Free-Wilson Analysis
• 3D-Quantitative Structure-Activity Relationship studies:
  • CoMFA Analysis
  • CoMSIA Analysis
• Molecular Modelling techniques:
  • Optimisation
  • Pharmacophore identification and generation
  • Docking